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In my lab, we're finding that psychological stress actually ages cells, which can be seen when you measure the wearing down of the tips of the chromosomes, those telomeres.
Elizabeth Blackburn
You
Stress
Seen
Down
Those
Finding
Wearing
Lab
Cells
Tips
Psychological
Which
Ages
Measure
Actually
Researchers have found that the brain definitely sends nerves directly to organs of the immune system and not just to the heart and the lower gut. In that way, too, the brain is influencing the body.
Elizabeth Blackburn
Heart
Too
Way
Definitely
System
Immune
Nerves
Gut
Directly
Brain
Sends
Just
Influencing
Lower
Body
Organs
Researchers
Found
In the 1970s, I did a Ph.D. with Fred Sanger in Cambridge who was in the process of inventing ways to map what's inside DNA. He later won the Nobel Prize.
Elizabeth Blackburn
Later
Ways
Inside
Fred
Inventing
He
Nobel
Nobel Prize
Cambridge
Won
Prize
Did
Process
Who
Map
Medicine has been successful by treating diseases in a very specific way once the damage is done. But telomere length integrates a lot of factors together and gives you an overall picture of risk for what is now emerging as a lot of diseases that tend to occur together, such as diabetes and heart disease.
Elizabeth Blackburn
You
Together
Heart
Diabetes
Picture
Medicine
Once
Way
Has-Been
Emerging
Risk
Gives
Tend
Factors
Overall
Occur
Been
Lot
Heart Disease
Very
Disease
Diseases
Done
Length
Successful
Now
Specific
Damage
Treating
The conservative statement is that telomere length is a biomarker, but it's probably not passive. There are some very intimate relationships between things such as molecular markers for inflammation and telomere health.
Elizabeth Blackburn
Health
Conservative
Markers
Relationships
Intimate
Statement
Some
Between
Passive
Very
Length
Molecular
Things
When scientists get old, they get interested in the brain, and I'm a little bit afraid I'm falling into that.
Elizabeth Blackburn
Old
Bit
Scientists
Falling
Brain
Get
Afraid
Interested
Little
Little Bit
Being senior enough in the field, having enough solidity, I don't feel afraid of being marginalized.
Elizabeth Blackburn
Field
Enough
Solidity
Having
Feel
Senior
Afraid
Being
Marginalized
Exercise mitigates the effects of stress - and stress, we know, shortens telomeres. In fact, early studies indicate that stress reduction techniques like meditation help people maintain the length of their telomeres.
Elizabeth Blackburn
People
Stress
Meditation
Indicate
Fact
Studies
Maintain
Like
Know
Exercise
Reduction
Effects
In Fact
Length
Help
Help People
Techniques
Early
We think there are lifestyle factors that boost telomerase naturally.
Elizabeth Blackburn
Think
Boost
Factors
Lifestyle
Naturally
If we think of our chromosomes - they carry our genetic material - as being like shoelaces, I work on the plastic tips at the end that protect them.
Elizabeth Blackburn
Work
Think
Our
Carry
Genetic
Like
Protect
Material
End
Tips
Being
Them
Plastic
Observational studies show that exercise, nutritional supplements and reducing psychological stress can help. Chronic high stress and smoking can lead to accelerated telomere shortening.
Elizabeth Blackburn
Smoking
Stress
Chronic
Nutritional
High
Lead
Supplements
Observational
Studies
Accelerate
Exercise
Reducing
Psychological
Shortening
Show
Help
Ageing is so many different things, and cells being able to self-renew is part of the picture but not all of it.
Elizabeth Blackburn
Picture
Able
Part
So Many Different Things
Cells
Being
Different
Ageing
Many
Different Things
Things
Red carpets are awful. They're like a kind of purgatory - you stand there, and there are cameras flashing everywhere. One of my first red carpets was in Cannes for 'The Great Gatsby,' and I'd never seen anything like it.
Elizabeth Debicki
Great
You
Seen
First
Everywhere
Great Gatsby
Kind
Purgatory
Never
Red
Red Carpets
Like
Cameras
Flashing
Cannes
Anything
Stand
Awful
I guess the bigger you dream, the further you have to fall if you don't get it, so it can be a bit of a scary thing to be that ambitious.
Elizabeth Debicki
You
Fall
Guess
Bit
Further
Dream
Scary
Scary Thing
Ambitious
Get
Bigger
Thing
Kissing in films, it's just another thing you have to do. It kind of becomes as technical as how to open a door, really.
Elizabeth Debicki
You
Films
Kind
Kissing
Open
Another
Becomes
How
Just
Door
Really
Technical
Thing
Every time I see a good play or watch a good movie, I have the same feeling I had as a child of wanting to be that person on stage or wanting to run through the forest with a big dress on.
Elizabeth Debicki
Time
Good
Feeling
Big
Stage
Every
Every Time
Good Movie
Run
See
Dress
Through
Had
Forest
Child
Person
Same
Movie
Wanting
Play
Watch
I was a dancer from a young age. My parents were dancers; we were taken to a lot of ballet as children. It occurred to me that what I liked more than dancing the steps was acting the story of whatever particular performance I was taking part in.
Elizabeth Debicki
Me
Age
Parents
Whatever
Young
Dancer
Dancers
Dancing
More
Part
Taken
Taking
Performance
Steps
Particular
Liked
Occurred
Ballet
Were
Lot
Than
Young Age
Children
Story
Acting
I was very new to working in front of the camera when I started shooting 'Gatsby', so I set myself the mission of gleaning as much information as possible out of the much more experienced actors. The cast was astoundingly talented.
Elizabeth Debicki
Myself
Out
Possible
More
Cast
New
Talented
Mission
Camera
Very
Shooting
Front
Experienced
Information
Much
Working
Actor
Started
Set
I have to say that filming 'The Night Manager' was not just amazing but also very daunting at first. I used to describe myself as the token plebeian surrounded by all your national treasures. All that glittering talent in one place; I knew Hugh from Fry and Laurie videos that my grandpa used to watch, and Tom Hollander's 'Rev' is hilarious.
Elizabeth Debicki
Myself
Amazing
Videos
First
Hilarious
National
Say
Daunting
Knew
Talent
Glittering
Also
Surrounded
Very
Hugh
Manager
Just
Place
Fry
Grandpa
Your
Used
Token
Describe
Tom
Watch
Treasures
Night
Filming
Often, female characters are quite one dimensional, especially in a two hour film; television gives characters room to breathe and develop.
Elizabeth Debicki
Television
Characters
One-Dimensional
Gives
Develop
Hour
Female
Female Characters
Quite
Often
Room
Breathe
Film
Two
I think there's something beautifully old fashioned about waiting all week then sitting down and watching something on television together. I'm generation box set, accustomed to binging on multiple episodes at a time, which is fun but quite a solitary pursuit because you do it alone.
Elizabeth Debicki
Alone
Time
You
Together
Generation
Waiting
Old
Down
Think
Television
Solitary
About
Something
Week
Pursuit
Beautifully
Box
Because
Sitting
Quite
Accustomed
Which
Then
Episodes
Old-Fashioned
Fun
Multiple
Watching
Set
There is something about a theatre room that is really like a laboratory for trying things and failing, because you have time to do that, and you can explore something deeply and discard it if it's not working.
Elizabeth Debicki
Time
You
Theatre
About
Something
Failing
Like
Discard
Because
Laboratory
Trying
Room
Really
Working
Explore
Deeply
Things
I am very tall, and when you're a teenager, you want to be like everyone else. I used to slump a lot; it's very human at that stage to want to be part of the crowd and not want any part of you that is sticking out.
Elizabeth Debicki
You
Stage
Else
Teenager
Everyone
Everyone Else
Out
Slump
Crowd
Part
Like
Tall
Sticking
Am
Lot
Very
Any
Human
Want
Used
I think I've developed a sort of ADD for geography now. When I've been in a country for too long, I'm like, 'I think it's time to leave.' I don't know what that's going to do to me in later life.
Elizabeth Debicki
Life
Time
Me
Long
Country
Think
Too
Add
Later
Developed
Like
Know
Sort
Geography
Leave
Been
Going
Now
Acting is a craft to me: I just think you get better the more you do it. And then the irony to that is your doing it is not in your control. If it was up to most actors, we'd work all the time, and we'd always get better. But it's not in our control, so we have to wait to be given parts to do.
Elizabeth Debicki
Work
Time
Me
You
Better
Wait
Control
Think
Our
Given
More
Most
Parts
Always
Doing
Up
Get
Irony
Craft
Just
Then
Acting
Your
Actor
It even sounds stupid to hear myself say the first costume designer I worked with was Catherine Martin, and she won an Oscar for it, but that was just my very lucky draw of roll of the dice.
Elizabeth Debicki
Myself
First
Stupid
Say
Draw
Martin
Costume
She
Catherine
Sounds
Hear
Dice
Won
Very
Roll
Just
Worked
Lucky
Even
Designer
Oscar
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