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Elizabeth Blackburn Quotes
Elizabeth Blackburn Quotes
Elizabeth Blackburn
Australian
Scientist
Born:
Nov 26
,
1948
Being
Cancer
Cells
Heart
Stress
You
Related authors:
Barry Marshall
Brian Schmidt
Greg Egan
Howard Florey
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Telomeres are the protective caps at the ends of chromosomes in cells. Chromosomes carry the genetic information. Telomeres are buffers. They are like the tips of shoelaces. If you lose the tips, the ends start fraying.
Elizabeth Blackburn
You
Lose
Carry
Genetic
Like
Protective
Cells
Tips
Ends
Information
Caps
Start
I chose biochemistry as my major and graduated after 4 years with an Honours degree in Biochemistry. During that time, I had come to love biochemistry research, although I was just getting my feet wet in laboratory research.
Elizabeth Blackburn
Love
Time
Degree
Research
Honours
Had
Major
Feet
Come
Although
Years
Laboratory
Wet
Getting
Graduated
Just
After
To Love
Chose
Biochemistry
In humans, the thing is that as we mature, our telomeres slowly wear down. So the question has always been: 'Did that matter?' Well, more and more, it seems like it matters.
Elizabeth Blackburn
Matter
Matters
Down
Our
Wear
Slowly
Seems
More
More And More
Like
Well
Always
Been
Question
Mature
Did
Thing
Humans
As maize became important for human food worldwide, modern agricultural research on maize breeding continued the corn breeding begun thousands of years ago in the Central American highlands.
Elizabeth Blackburn
Food
Important
Research
Corn
Worldwide
Thousands
Thousands Of Years
Became
Continue
Years
Years Ago
Begun
American
Modern
Human
Central
Breeding
Agricultural
What is it that keeps you so interested in the telomere? It's so intricate and complicated, and you want to know how it works.
Elizabeth Blackburn
You
Complicated
Intricate
Know
How
Want
Interested
Works
Keeps
We and other groups are seeing clear statistical links between telomere shortness and risk for a variety of diseases that are becoming very common, such as cardiovascular disease, diabetes and certain cancers.
Elizabeth Blackburn
Diabetes
Other
Statistical
Seeing
Risk
Variety
Clear
Between
Becoming
Very
Links
Disease
Diseases
Cancers
Common
Shortness
Certain
Groups
Cardiovascular
If a test showed you had telomere shortening, it would be a red flag suggesting you should take a look at possible risk factors.
Elizabeth Blackburn
You
Possible
Would
Would-Be
Risk
Factors
Take
Had
Red
Look
Test
Flag
Shortening
Should
Suggesting
I was born in the small city of Hobart in Tasmania, Australia, in 1948. My parents were family physicians. My grandfather and great grandfather on my mother's side were geologists.
Elizabeth Blackburn
Great
Family
Mother
Parents
Side
City
Born
Small
Physicians
Great-Grandfather
Were
Australia
Grandfather
I spent my first 4 years living in the tiny town of Snug, by the sea near Hobart. Curious about animals, I would pick up ants in our backyard and jellyfish on the beach.
Elizabeth Blackburn
Animals
First
Living
Our
Spent
Backyard
Would
About
Beach
Pick
Town
Years
Up
Curious
Ants
Tiny
Sea
Near
Perhaps arising from a fascination with animals, biology seemed the most interesting of sciences to me as a child.
Elizabeth Blackburn
Me
Animals
Biology
Seemed
Arising
Perhaps
Most
Sciences
Child
Interesting
Fascination
Tracing the beginnings of the interwoven stories of science can be arbitrary, as beginnings are so often lost in the mists of time.
Elizabeth Blackburn
Time
Science
Lost
Interwoven
Arbitrary
Tracing
Beginnings
Often
Stories
In my early work, our molecular views of telomeres were first focused on the DNA.
Elizabeth Blackburn
Work
First
Early Work
Our
Focused
Were
Molecular
Views
Early
I was using very unconventional methods to sequence the telemetric DNA, originally.
Elizabeth Blackburn
Unconventional
Methods
Very
Sequence
Using
Originally
I've only actively promoted what we always hope is good science.
Elizabeth Blackburn
Hope
Good
Science
Promoted
Only
Always
Actively
In my lab, we're finding that psychological stress actually ages cells, which can be seen when you measure the wearing down of the tips of the chromosomes, those telomeres.
Elizabeth Blackburn
You
Stress
Seen
Down
Those
Finding
Wearing
Lab
Cells
Tips
Psychological
Which
Ages
Measure
Actually
Researchers have found that the brain definitely sends nerves directly to organs of the immune system and not just to the heart and the lower gut. In that way, too, the brain is influencing the body.
Elizabeth Blackburn
Heart
Too
Way
Definitely
System
Immune
Nerves
Gut
Directly
Brain
Sends
Just
Influencing
Lower
Body
Organs
Researchers
Found
In the 1970s, I did a Ph.D. with Fred Sanger in Cambridge who was in the process of inventing ways to map what's inside DNA. He later won the Nobel Prize.
Elizabeth Blackburn
Later
Ways
Inside
Fred
Inventing
He
Nobel
Nobel Prize
Cambridge
Won
Prize
Did
Process
Who
Map
Medicine has been successful by treating diseases in a very specific way once the damage is done. But telomere length integrates a lot of factors together and gives you an overall picture of risk for what is now emerging as a lot of diseases that tend to occur together, such as diabetes and heart disease.
Elizabeth Blackburn
You
Together
Heart
Diabetes
Picture
Medicine
Once
Way
Has-Been
Emerging
Risk
Gives
Tend
Factors
Overall
Occur
Been
Lot
Heart Disease
Very
Disease
Diseases
Done
Length
Successful
Now
Specific
Damage
Treating
The conservative statement is that telomere length is a biomarker, but it's probably not passive. There are some very intimate relationships between things such as molecular markers for inflammation and telomere health.
Elizabeth Blackburn
Health
Conservative
Markers
Relationships
Intimate
Statement
Some
Between
Passive
Very
Length
Molecular
Things
When scientists get old, they get interested in the brain, and I'm a little bit afraid I'm falling into that.
Elizabeth Blackburn
Old
Bit
Scientists
Falling
Brain
Get
Afraid
Interested
Little
Little Bit
Being senior enough in the field, having enough solidity, I don't feel afraid of being marginalized.
Elizabeth Blackburn
Field
Enough
Solidity
Having
Feel
Senior
Afraid
Being
Marginalized
Exercise mitigates the effects of stress - and stress, we know, shortens telomeres. In fact, early studies indicate that stress reduction techniques like meditation help people maintain the length of their telomeres.
Elizabeth Blackburn
People
Stress
Meditation
Indicate
Fact
Studies
Maintain
Like
Know
Exercise
Reduction
Effects
In Fact
Length
Help
Help People
Techniques
Early
We think there are lifestyle factors that boost telomerase naturally.
Elizabeth Blackburn
Think
Boost
Factors
Lifestyle
Naturally
If we think of our chromosomes - they carry our genetic material - as being like shoelaces, I work on the plastic tips at the end that protect them.
Elizabeth Blackburn
Work
Think
Our
Carry
Genetic
Like
Protect
Material
End
Tips
Being
Them
Plastic
Observational studies show that exercise, nutritional supplements and reducing psychological stress can help. Chronic high stress and smoking can lead to accelerated telomere shortening.
Elizabeth Blackburn
Smoking
Stress
Chronic
Nutritional
High
Lead
Supplements
Observational
Studies
Accelerate
Exercise
Reducing
Psychological
Shortening
Show
Help
Ageing is so many different things, and cells being able to self-renew is part of the picture but not all of it.
Elizabeth Blackburn
Picture
Able
Part
So Many Different Things
Cells
Being
Different
Ageing
Many
Different Things
Things
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