Martin Chalfie quote

We have found that fusions of GFP with the RING finger domains of certain E3 ubiquitin ligases creates an unstable GFP. We have used unstable GFP to learn how disruption of microtubules in the touch receptor neurons causes a generalized reduction in protein levels in the cells.
Martin Chalfie

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"Nobel Prize in Chemistry" Martin Chalfie Signed 3X4.5 Photo Todd Mueller COA
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