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Martin Chalfie Quotes
Martin Chalfie Quotes
Martin Chalfie
American
Scientist
Born:
Jan 15
,
1947
Animals
Me
Molecules
Problem
Science
Sense
Related authors:
Ben Carson
Carl Sagan
E. O. Wilson
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W. Edwards Deming
Scientific inquiry starts with observation. The more one can see, the more one can investigate.
Martin Chalfie
Starts
Inquiry
See
More
Investigate
Observation
Scientific
If you do an experiment and it gives you what you did not expect, it is a discovery.
Martin Chalfie
You
Experiment
Gives
Discovery
Expect
Did
One of the great things about working on C. elegans was the fact that it was transparent, and so when I first heard that seminar describing GFP, and realised, 'I work on this transparent animal, this is going to be terrific! I'll be able to see the cells within the living animal.'
Martin Chalfie
Work
Great
Animal
Great Things
First
Living
See
Able
About
Fact
Terrific
Within
Heard
Seminar
Going
Cells
Realised
Working
Transparent
Describing
Things
I entered Harvard in 1965 not really knowing what I wanted to do. This confusion seems to have lost me a fellowship. G. D. Searle and Company, the pharmaceutical firm, had their home office in Skokie, and they gave a fellowship each year to a graduate from my high school that was going to major in science in college.
Martin Chalfie
Home
Me
Science
School
Confusion
College
Year
Lost
Gave
Harvard
Entered
High
High School
Seems
Had
Firm
Major
Knowing
Fellowship
Office
Graduate
Going
Wanted
Really
Company
Each
Each Year
Pharmaceutical
I had been interested in science from when I was very young, but after a disastrous summer lab experience in which every experiment I tried failed, I decided on graduating from college that I was not cut out to be a scientist.
Martin Chalfie
Science
Experience
College
Young
Experiment
Every
Summer
Out
Tried
Had
Failed
Disastrous
Scientist
Been
Lab
Very
Graduating
After
Decided
Which
Interested
Cut
We have found that fusions of GFP with the RING finger domains of certain E3 ubiquitin ligases creates an unstable GFP. We have used unstable GFP to learn how disruption of microtubules in the touch receptor neurons causes a generalized reduction in protein levels in the cells.
Martin Chalfie
Ring
Finger
Touch
Neurons
Generalized
Unstable
Learn
Protein
How
Reduction
Causes
Domains
Cells
Creates
Certain
Used
Found
Levels
Disruption
I do think of this prize as the GFP prize, and I happen to fortunately be one of the people that goes along for the ride.
Martin Chalfie
People
Ride
Think
Along
Prize
Goes
Happen
Fortunately
What I am primarily is a neurogeneticist: I use genetics to study problems in neurobiology. The one problem I study primarily... understanding of the sense of touch.
Martin Chalfie
Problem
Problems
Understanding
Sense
Touch
Primarily
Study
Genetics
Am
Use
We know what molecules are needed to sense light - what turns that signal that detects light into an electrical signal. We know how smells are detected. But we have a vast number of senses for which we know what the signal is, but we don't know what the receiver is.
Martin Chalfie
Light
Sense
Signal
Vast
Know
Smells
How
Senses
Which
Turns
Molecules
Electrical
Receiver
Number
Needed
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