Francis Crick Quotes

Francis Crick
Francis Crick
English Scientist
Born: Jun 8, 1916
Died: Jul 28, 2004
Acid Amino Amino Acid Base Certain Genetic
Related authors: Ashley Montagu Charles Darwin Erasmus Darwin Jacob Bronowski Jane Goodall Matthew Walker Richard Dawkins Thomas Huxley
The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar. Francis Crick
Balance Random Evidence System Mutation Triplets Similar Rather Both Study Well Does Occur Same May Acid Amino Amino Acid Coding
Moreover the incorporation requires the same components needed for protein synthesis, and is inhibited by the same inhibitors. Thus the system is most unlikely to be a complete artefact and is very probably closely related to genuine protein synthesis. Francis Crick
Related Complete Unlikely Synthesis System Components Moreover Thus Most Protein Genuine Very Closely Same Requires Inhibited Needed
Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets. Francis Crick
Made Own Changes Relative Reliable Mutation Composition Triplets Data My Own More Various Attempts Study Until Obtain Within Been Order Produced View Premature Bases Extensive
We are sometimes asked what the result would be if we put four +'s in one gene. To answer this my colleagues have recently put together not merely four but six +'s. Francis Crick
Together Result Sometimes Colleagues Would Would-Be Gene Put Merely Answer Six Asked Four Recently
It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code. Francis Crick
Nature Other Our Secure Would Triplets About General Rather Only Since Genetic Come Occasionally Conclusion Nonsense However Than Low Them Across Less Deduction Appear Code Number
It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid. Francis Crick
Distinct Several Possibly Triplets Seems General Most Likely Another Very May Acid Them Many Amino Amino Acid Code Now
It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule. Francis Crick
Some Determined Seems Particular Protein Any Acid Region Certain Molecule Sequence Amino Amino Acid Now Bases
It is one of the more striking generalizations of biochemistry - which surprisingly is hardly ever mentioned in the biochemical textbooks - that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature. Francis Crick
Nature Striking Minor More Mentioned Throughout Generalizations Surprisingly Textbooks Same Which Reservations Twenty Amino Ever Bases Biochemical Biochemistry Hardly Four
It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code. Francis Crick
Indeed Evidence Direct Indirect Mentioned Genetic Opposed Methods Shown Code Biochemical Earlier
If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it. Francis Crick
Good Logical Consider Indeed Evidence Bad Some Both Attempt Does Any Legitimate Then Good And Bad Deduce Code Foundation
The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one amino acid. However one would certainly expect such triplets to be in a minority. Francis Crick
Minority Possibility Would Triplets More Unclear Observation However Ambiguous Expect Than May Acid Unfortunate Which Meaning Meaning Of Certainly Amino Amino Acid Code Raises
Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap. Francis Crick
Words Other Member Find Seems More Genetic Along Message Fairly Read Overlap In Other Words Which Certain Base Now Two
A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement. Francis Crick
Changes Mutation Triplets Between Fair Methods Acid Produced Measure Sequence Shows Agreement Amino Amino Acid Comparison

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